Core-11 Molecular Biology 5th sem zoollogy Honours
2. Explain precisely any two of the following:
4x2=81
(a) DNA polymerase-III
(b) Repair of DNA molecule (c) RNA interference
3. Write explanatory notes on any two of the following:
4x2=8
-a) Wobble hypothesis
tRNA structure and function
(c) Processing of mRNA
(d) Okazaki fragment
4. Describe the structure of DNA double-helix model. Explain the synthesis of lagging strand of DNA with suitable diagram(s). 4+4=8
Or
Explain with suitable diagram(s) the experiment that conclusively proved that DNA replicates in semiconservative way. Why is DNA replication said to be semi discontinuous?
5. What are the sequence elements found in the promoter of genes transcribed by RNA pol ? Write a short note on General Transcription Factors (GTFs) and their roles in transcription of mRNA in eukaryotes. 345-8 Or
Write short notes on Rho-dependent and Rho-independent termination of prokaryotic transcription. How transcription in prokaryotes differ from eukaryotes? 4+4-8
6. Write the biochemical reaction catalyzed by
aminoacyl-tRNA synthetase. Write a note with
suitable diagram on the formation of initiation
Or
complex in bacterial protein biosynthesis. 3+5=8 Elaborate the process of elongation of protein synthesis in prokaryotes.
7. It E. coli is grown in a medium containing both glucose and lactose, which carbon source will it prefer and why? Explain your answer with reference to operon concept using suitable diagrams. 1+5+2=8
Or
What is operon? Describe the structure of tryptophan operon. Add a note on eukaryotic transcription activators and repressors.
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