1. (a) Choose the correct answer following: 1×3=3
(i) The web-based sequence submis sion tool of EMBL is Sakura / Webin/Entrez / Banklt.
(ii) The term Bioinformatics was coined by Hogeweg and Hesper / Margaret Dayhoff/ Christian D. Wunsch / Temple F. Smith.
(iii) NCBI stands for National Center for Biotechnology Information 1 National Center of Biotechnological Information / National Council of Biological Information / National Council of Biotechnological Institute.
(b) Fill in the blanks : 1x2=2
(i) BLAST stands for biological
(i) The branching pattern of phylogenetic tree is called a______
2. Write on the following in short: fay/sw (a)SwissProt
(b) QSAR.
(c) FASTA
(d) Percent Accepted Mutation
3, What is biological sequence alignment? Distinguish between local and global alignment. Also, write briefly on the dynamic programming method of biological sequence alignment. o itong 2+2+8=12
Or
Align the following sequences using Needleman-Wunsch algorithm and find out the alignment scoreidd to v 9+3=12
Seq. 1 ATGCTGTA
Seq. 2 ATCTATA
where, Match score = +1; Mismatch = 0; Gap Penalty = -1
4. What are biological databases? What are the major functions of biological databases? With suitable examples, write briefly about different types of biological database. 2+2+8=12
Or
Define bioinformatics. What are the aim and scopes of it? Distinguish between Bioinformatics and Computational Biology.
2+6+4=12
5.What is phylogenetic analysis? Define phylogenetic tree. Also write the types of phylogenetic tree. Write briefly the steps involved in the construction of a molecular phylogenetic tree. 2+1+4+5=12
Or
What does the acronym DDBJ stand for? Where is DDBJ located? What are the objectives of DDBJ? How to submit a sequence in DDBJ? 2+1+3+6=12
